3 years ago

ChannelsDB: database of biomacromolecular tunnels and pores.

Jaroslav Koca, Radka Svobodová Vareková, Dominik Toušek, David Sehnal, Lukáš Pravda, Veronika Navrátilová, Michal Otyepka, Karel Berka
ChannelsDB (http://ncbr.muni.cz/ChannelsDB) is a database providing information about the positions, geometry and physicochemical properties of channels (pores and tunnels) found within biomacromolecular structures deposited in the Protein Data Bank. Channels were deposited from two sources; from literature using manual deposition and from a software tool automatically detecting tunnels leading to the enzymatic active sites and selected cofactors, and transmembrane pores. The database stores information about geometrical features (e.g. length and radius profile along a channel) and physicochemical properties involving polarity, hydrophobicity, hydropathy, charge and mutability. The stored data are interlinked with available UniProt annotation data mapping known mutation effects to channel-lining residues. All structures with channels are displayed in a clear interactive manner, further facilitating data manipulation and interpretation. As such, ChannelsDB provides an invaluable resource for research related to deciphering the biological function of biomacromolecular channels.

Publisher URL: http://doi.org/10.1093/nar/gkx868

DOI: 10.1093/nar/gkx868

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