3 years ago

Assessment of Omega‐3 Carboxylic Acids in Statin Treated Patients with High Levels of Triglycerides and Low Levels of High Density Lipoprotein Cholesterol: Rationale and Design of the STRENGTH Trial

Michael H. Davidson, Dariush Mozaffarian, Philip J Barter, Torbjörn Lundström, Wolfgang Koenig, Terje R Pedersen, Steven E Nissen, A Michael Lincoff, Kausik Ray, Christie M Ballantyne, Björn W Karlson, Stephen J Nicholls, John J.P. Kastelein, Darren K. McGuire, Kathy Wolski, Dianna Bash, Paul M Ridker

Abstract

Background

It is uncertain whether omega‐3 fatty acids are beneficial in statin‐treated patients. Epanova is a mix of omega‐3 free fatty acids, not requiring co‐ingestion with food, which can lower triglycerides by up to 31%. STRENGTH will examine whether Epanova 4 g daily reduces the rate of cardiovascular events in statin‐treated patients with hypertriglyceridemia and low levels of HDL‐C at high risk for developing cardiovascular events.

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