3 years ago

Intestinal host defense outcome is dictated by PGE2 production during efferocytosis of infected cells [Immunology and Inflammation]

Intestinal host defense outcome is dictated by PGE2 production during efferocytosis of infected cells [Immunology and Inflammation]
Naiara Naiana Deȷani, Ana Campos Codo, Julia Miranda Ribeiro Bazzano, Felipe Fortino Verdan, Ana Carolina Guerta Salina, C. Henrique Serezani, Alexandra Ivo Medeiros, Leticia de Aquino Penteado, Amanda Correia Saraiva, Matheus Rossi Avelar, Luis Carlos Spolidorio, Victoria Eugenia Nino, Allan Botinhon Orlando

Inflammatory responses are terminated by the clearance of dead cells, a process termed efferocytosis. A consequence of efferocytosis is the synthesis of the antiinflammatory mediators TGF-β, PGE2, and IL-10; however, the efferocytosis of infected cells favors Th17 responses by eliciting the synthesis of TGF-β, IL-6, and IL-23. Recently, we showed that the efferocytosis of apoptotic Escherichia coli-infected macrophages by dendritic cells triggers PGE2 production in addition to pro-Th17 cytokine expression. We therefore examined the role of PGE2 during Th17 differentiation and intestinal pathology. The efferocytosis of apoptotic E. coli-infected cells by dendritic cells promoted high levels of PGE2, which impaired IL-1R expression via the EP4-PKA pathway in T cells and consequently inhibited Th17 differentiation. The outcome of murine intestinal Citrobacter rodentium infection was dependent on the EP4 receptor. Infected mice treated with EP4 antagonist showed enhanced intestinal defense against C. rodentium compared with infected mice treated with vehicle control. Those results suggest that EP4 signaling during infectious colitis could be targeted as a way to enhance Th17 immunity and host defense.

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