3 years ago

Mitochondria-targeted betulinic and ursolic acid derivatives: synthesis and anticancer activity

Mitochondria-targeted betulinic and ursolic acid derivatives: synthesis and anticancer activity
Yuriy P. Bel'skii, Darya A. Nedopekina, Anna Yu. Spivak, Vladimir Gogvadze, Rinat R. Gubaidullin, Boris Zhivotovsky, Arina V. Manuylova, Victor N. Odinokov, Veniamin A. Khazanov, Polina V. Maximchik
Conjugation of native triterpenoids, namely, betulinic and ursolic acids, with a lypophilic triphenylphosphonium cation led to the dramatic enhancement, as compared to betulinic acid, of their ability to trigger the mitochondrial apoptosis pathway in various types of cancer cells.

Publisher URL: http://feeds.rsc.org/~r/rss/MD/~3/JTdMubq3LkY/C7MD00248C

DOI: 2017/MD/C7MD00248C

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