Pyrimidine nucleotides containing a (S)-methanocarba ring as P2Y6 receptor agonists

4 years ago

Pyrimidine nucleotides containing a (S)-methanocarba ring as P2Y6 receptor agonists

Kiran S. Toti, Ryan Surujdin, Antonella Ciancetta, Kenneth A. Jacobson, Zhen-Dan Shi, Saibal Chakraborty, Ramachandran Balasubramanian, Shanu Jain

Uracil nucleotides containing a south-bicyclo[3.1.0]hexane ((S)-methanocarba) ring system in place of the ribose ring were synthesized and shown to be potent P2Y₆R agonists in a calcium mobilization assay.

Publisher URL: http://feeds.rsc.org/~r/rss/MD/~3/DYkZyyYxMC4/C7MD00397H

DOI: 2017/MD/C7MD00397H

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