European Journal of Inorganic Chemistry
European Journal of Inorganic Chemistry
4 years ago

Closomers: Versatile Monodisperse Molecular Nanoparticles

Closomers: Versatile Monodisperse Molecular Nanoparticles
Satish S. Jalisatgi, Alexander V. Safronov, M. Frederick Hawthorne
This review is dedicated to a relatively new, but nevertheless very quickly evolving field of chemistry – closomer chemistry. Closomers are complex organoelement molecules built on a [B12]2– icosahedral platform that have the combined benefits of the symmetry and stability of polyhedral boranes and the diversity of organic chemistry. On a material level, closomers can be considered as monodisperse molecular nanoparticles because of their size, spherical symmetry, and ease of adjusting the arm length. The ease of twelvefold side-chain functionalization and the possibility of heterosubstitution makes closomers very useful medical tools for targeted and traceable imaging and drug delivery applications. This review is dedicated to the chemistry of closomers – monodisperse molecular nanoparticles built on a [B12]2– icosahedral platform, incorporating combined benefits of polyhedral boranes and organic molecules. The diverse side-chain functionalization and heterosubstitution possibilities make closomers very useful medical tools for targeted and traceable imaging and drug delivery applications.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/ejic.201700594

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