3 years ago

Conserved nucleolar stress at the onset of cell death

Conserved nucleolar stress at the onset of cell death
Pierre Golstein
Cell death pervasiveness among multicellular eukaryotes suggested that some core steps of cell death may be conserved. This could be addressed by comparing the course of cell death in organisms belonging to distinct eukaryotic kingdoms. A search for early cell death events in a protist revealed nucleolar disorganization similar to the nucleolar stress often reported in dying animal cells. This indicated a conserved role for the nucleolus at the onset of eukaryotic cell death and leads one to consider the course of cell death as a succession of unequally conserved modules. rRNA synthesis inhibition and nucleolar disorganization were shown to occur early in the course of at least some instances of cell death, not only in animals and plants but also in protists. This emphasized unequal conservation of distinct modules in the course of cell death, with a more widely conserved and presumably more ancient nucleolar disorganization module preceding effector modules.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/febs.14095

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