5 years ago

3q26-29 Amplification in head and neck squamous cell carcinoma: a review of established and prospective oncogenes

3q26-29 Amplification in head and neck squamous cell carcinoma: a review of established and prospective oncogenes
Matthew A. Davidson, Emma J. Shanks
Head and neck squamous cell carcinoma (HNSCC) is significantly underrepresented in worldwide cancer research, yet survival rates for the disease have remained static for over 50 years. Distant metastasis is often present at the time of diagnosis, and is the primary cause of death in cancer patients. In the absence of routine effective targeted therapies, the standard of care treatment remains chemoradiation in combination with (often disfiguring) surgery. A defining characteristic of HNSCC is the amplification of a region of chromosome 3 (3q26-29), which is consistently associated with poorer patient outcome. This review provides an overview of the role the 3q26-29 region plays in HNSCC, in terms of both known and as yet undiscovered processes, which may have potential clinical relevance. The 5-year survival rate of head and neck squamous cell carcinoma (HNSCC) with distant metastasis has remained at 40–50% for over 50 years. Thus far, cetuximab is the only targeted agent which has been approved for the treatment of locally advanced HNSCC, highlighting the need for novel targeted agents. Amplification of 3q26-29 is the most frequently observed genomic alteration in HNSCC, and is associated with poor clinical outcome.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/febs.14061

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