Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
4 years ago

Copper-Catalyzed Synthesis and Applications of Yndiamides

Copper-Catalyzed Synthesis and Applications of Yndiamides
Aroonroj Mekareeya, Kirsten E. Christensen, Kai Ma, Michael W. Jones, Amber L. Thompson, Edward A. Anderson, Steven J. Mansfield
The first synthetic route to yndiamides, a novel class of double aza-substituted alkyne, has been established by the copper(I)-catalyzed cross-coupling of 1,1-dibromoenamides with nitrogen nucleophiles. The utility of these compounds is demonstrated in a range of transition-metal-catalyzed and acid-catalyzed transformations to afford a wide variety of 1,2-diamide functionalized products. Die, amide! The first synthetic route to yndiamides, a novel class of double aza-substituted alkyne, has been established by the copper(I)-catalyzed cross-coupling of 1,1-dibromoenamides with nitrogen nucleophiles. The utility of these compounds is demonstrated in a range of transition-metal-catalyzed and acid-catalyzed transformations to afford a wide variety of 1,2-diamide functionalized products.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201706915

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