3 years ago

Cover Picture: A Pyrene-Linked Cavity within a β-Barrel Protein Promotes an Asymmetric Diels–Alder Reaction (Angew. Chem. Int. Ed. 44/2017)

Cover Picture: A Pyrene-Linked Cavity within a β-Barrel Protein Promotes an Asymmetric Diels–Alder Reaction (Angew. Chem. Int. Ed. 44/2017)
Naomasa Taniguchi, Takashi Hayashi, Shunsuke Kato, Akira Onoda, Tomoki Himiyama
A pyrene-linked protein cavity attracts two substrate molecules like the scent of a flower attracts butterflies. In their Communication on page 13618 ff., A. Onoda, T. Hayashi, and co-workers demonstrate that a polycyclic pyrene moiety linked within the rigid protein scaffold of the β-barrel of nitrobindin acts as a platform to provide an aromatic interaction with a substrate. An asymmetric Diels–Alder reaction between azachalcone and cyclopentadiene proceeds smoothly with high stereoselectivity within the reaction scaffold.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201710001

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