3 years ago
Expanding the Structural Space of Ribosomal Peptides: Autocatalytic N-Methylation in Omphalotin Biosynthesis
Hülya Aldemir, Tobias A. M. Gulder
Tail-Me: The N-methylation of backbone amide bonds in peptide natural products was thought to be exclusive to non-ribosomal peptides. A newly discovered methylation mechanism now brings this structural feature into the world of ribosomal peptides, thereby significantly expanding the structural diversity of ribosomally synthesized and post-translationally modified peptides (RiPPs).
Publisher URL: http://onlinelibrary.wiley.com/resolve/doi
DOI: 10.1002/anie.201708456
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