Black Pigment Gallstone Inspired Platinum-Chelated Bilirubin Nanoparticles for Combined Photoacoustic Imaging and Photothermal Therapy of Cancers

Angewandte Chemie - International Edition

4 years ago

Black Pigment Gallstone Inspired Platinum-Chelated Bilirubin Nanoparticles for Combined Photoacoustic Imaging and Photothermal Therapy of Cancers

Hyeon Sik Kim, Jung-Joon Min, Wenjun Miao, Jin Yong Kim, Soyoung Lee, Dong Yun Lee, Sangyong Jon, Yonghyun Lee

Bilirubin (BR), a bile pigment that exerts potent antioxidant and anti-inflammatory effects, is also a major constituent of black pigment gallstones found in bile ducts under certain pathological conditions. Inspired by the intrinsic metal-chelating power of BR found in gallstones, herein we report a cisplatin-chelated BR-based nanoparticle (cisPt@BRNP) for use as a new photonic nanomedicine for combined photoacoustic imaging and photothermal therapy of cancers. The cisPt@BRNPs were prepared by simply mixing cisplatin with BRNPs, yielding ca. 150-nm-size NPs. Upon near-IR laser irradiation at 808 nm, cisPt@BRNPs generated considerable heat and induced clear death of cancer cells in vitro. Following intravenous injection into human colon cancer-bearing mice, cisPt@BRNPs allowed effective tumor visualization by photoacoustic imaging and remarkable antitumor efficacy by photothermal therapy, suggesting their potential for use as a new photonic nanomedicine for cancer therapy. The gall of it: A new class of near infrared light-responsive photonic nanomaterial which is biodegradable and biocompatible is developed based on the inherent metal-chelating ability of bilirubin, a bile pigment found in gall stones. The resulting cisplatin-chelated bilirubin nanoparticles (cisPt@BRNPs) are promising for combined photoacoustic imaging (PAI) and photothermal therapy (PTT) of cancers.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201707137