Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
4 years ago

Catanionic Coacervate Droplets as a Surfactant-Based Membrane-Free Protocell Model

Catanionic Coacervate Droplets as a Surfactant-Based Membrane-Free Protocell Model
Jean-Paul Douliez, Stephen Mann, Laure Beven, Thomas Beneyton, Nicolas Martin, Cédric Gaillard, Jean-Christophe Baret
We report on the formation of surfactant-based complex catanionic coacervate droplets in mixtures of decanoic acid and cetylpyridinium chloride or cetyltrimethylammonium bromide. We show that coacervation occurs over a broad range of composition, pH, and ionic strength. The catanionic coacervates consist of elongated micelles, sequester a wide range of solutes including water-soluble organic dyes, polysaccharides, proteins, enzymes, and DNA, and can be structurally stabilized by sodium alginate or gelatin-based hydrogelation. These results suggest that catanionic coacervates could be exploited as a novel surfactant-based membrane-free protocell model. Catanionic coacervates as protocells: Proteins, enzymes, and DNA are spontaneously sequestered within catanionic surfactant coacervates, thereby affording a novel protocell model.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201707139

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