Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
4 years ago

A Biomimetic Escape Strategy for Cytoplasm Invasion by Synthetic Particles

A Biomimetic Escape Strategy for Cytoplasm Invasion by Synthetic Particles
Laura Marín-Caba, Miguel A. Correa-Duarte, Elena González-Domínguez, Nerea Iturrioz-Rodríguez., Monica L. Fanarraga, Moisés Pérez-Lorenzo, Eloisa González-Lavado, Belén Vaz
The translocation of nanomaterials or complex delivery systems into the cytosol is a major challenge in nanobiotechnology. After receptor-mediated endocytosis, most nanomaterials are sequestered and undergo degradation, therapy inactivation, or exocytosis. Herein we explore a novel surface particle coating made of adsorbed carbon nanotubes that provides coated materials with new properties that reproduce the viral cell-invasive mechanisms, namely, receptor-mediated endocytosis, endolysosomal escape, and cytosolic particle release preserving cell viability. This novel biomimetic coating design will enable the intracytoplasmic delivery of many different functional materials endowed with therapeutic, magnetic, optical, or catalytic functionalities, thus opening the door to a wide array of chemical and physical processes within the cytosolic or nuclear domains, and supporting new developments in the biotechnological, pharmaceutical, and biomedical industries. A clean getaway: An engineered nanocoating composed of carbon nanotubes enabled particles with nano/micrometer dimensions to break through lysosomal membranes and invade the intracellular realm (see picture). The coated materials resemble viruses in terms of their structure and reproduce the viral cell-invasive mechanisms of receptor-mediated endocytosis, endolysosomal escape, and cytosolic particle release with the preservation of cell viability.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201707769

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.