Journal of Organic Chemistry
Journal of Organic Chemistry
4 years ago

One-Pot Synthesis of Quinoxalinones via Tandem Nitrosation/Cyclization of N-Aryl Cyanoacetamides

One-Pot Synthesis of Quinoxalinones via Tandem Nitrosation/Cyclization of N-Aryl Cyanoacetamides
Hai-Yong Tu, Lizhi Liu, Xing-Guo Zhang, Bo-Lun Hu, Fang Wang
A new one-pot strategy for the synthesis of quinoxalin-2-ones from the tandem nitrosation/cyclization reaction of N-aryl cyanoacetamides with tert-butyl nitrite has been developed. The dehydrogenative N-incorporation is achieved through a sequence of nitrosation, tautomerization, and cyclization, affording quinoxalin-2-ones in moderate to good yields with good functional group tolerance.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01930

DOI: 10.1021/acs.joc.7b01930

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