3 years ago

Difluorocarbene for Dehydroxytrifluoromethylthiolation of Alcohols

Difluorocarbene for Dehydroxytrifluoromethylthiolation of Alcohols
Jin-Hong Lin, Ji-Chang Xiao, Min Zhang, Jia-Jia Luo
Dehydroxytrifluoromethylthiolation of alcohols with a Ph3P+CF2CO2/S8/F system is described. Difluorocarbene generated from Ph3P+CF2CO2 would readily combine with elemental sulfur to furnish S═CF2. S═CF2 can be considered as a bifunctional intermediate, activating alcohol and providing scaffold for CF3S formation, thus allowing for the convenient dehydroxytrifluoromethylthiolation of alcohols.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01701

DOI: 10.1021/acs.joc.7b01701

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