Catalytic Asymmetric 1,3-Dipolar Cycloaddition/Hydroamination Sequence: Expeditious Access to Enantioenriched Pyrroloisoquinoline Derivatives

4 years ago

Catalytic Asymmetric 1,3-Dipolar Cycloaddition/Hydroamination Sequence: Expeditious Access to Enantioenriched Pyrroloisoquinoline Derivatives

Alba Molina, Ana Pascual-Escudero, Javier Adrio, Juan C. Carretero

A three-step reaction sequence has been developed to prepare a variety of enantioenriched pyrroloisoquinoline derivatives. The process involves a catalytic asymmetric azomethine ylide 1,3-dipolar cycloaddition followed by an intramolecular Au^I-catalyzed alkyne hydroamination and enamine reduction.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01927

DOI: 10.1021/acs.joc.7b01927

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