ACS Catalysis
ACS Catalysis
5 years ago

Pd-Catalyzed Regioselective Decarboxylative/C–H α-Alkoxyalkenylation of Heterocycles Using α-Carboxyvinylethers

Pd-Catalyzed Regioselective Decarboxylative/C–H α-Alkoxyalkenylation of Heterocycles Using α-Carboxyvinylethers
Mahmoud Hachem, Christophe Hoarau, Jean-Baptiste E. Y. Rouchet, Cédric Schneider
A direct introduction of vinyl ethers into C–H bond of heterocycles is reported. For this purpose, decarboxylative direct C–H cross-coupling of 1,3-diazoles with α-carboxyvinyl ethers as coupling partners was achieved under Pd(0)/Cu(I) cooperative catalysis to produce various α-heteroarylated vinylethers. This methodology was applied to the innovative production of heteroarylated enolizable ketones and naturally occurring bis-oxa(thia)zoles.

Publisher URL: http://dx.doi.org/10.1021/acscatal.7b01330

DOI: 10.1021/acscatal.7b01330

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