3 years ago

Ligand-Assisted Heteroaryl C(sp2)−H Bond Activation by a Cationic Ruthenium(II) Complex for Alkenylation of Heteroarenes with Alkynes Directed by Biorelevant Heterocycles

Ligand-Assisted Heteroaryl C(sp2)−H Bond Activation by a Cationic Ruthenium(II) Complex for Alkenylation of Heteroarenes with Alkynes Directed by Biorelevant Heterocycles
Asit K. Chakraborti, Bhavin V. Pipaliya
Alkenylation of heteroarenes with alkynes has been achieved through ligand-assisted heteroaryl C(sp2)−H bond activation by an in situ generated cationic RuII complex directed by the biorelevant heterocyclic scaffolds benzothiazole and benzoxazole, giving broad scope with respect to the heteroarenes (thiophene, furan, N-methyl pyrrole, and 3-indole) and the alkynes (diaryl, dialkyl, and aryl alkyl) in high yields and with high stereo- and regioselectivities. (Hetero)cycling there: Heteroaryl C(sp2)−H bond activation has been catalyzed by an in situ generated cationic RuII complex for alkenylation of heteroarenes with alkynes directed by biorelevant benzazoles. The reaction has broad scope with respect to the heteroarene (e.g., thiophene, furan, N-methyl pyrrole, and 3-indole) and the alkyne (symmetrical and unsymmetrical diaryl, dialkyl, aryl alkyl alkynes), affording high yields and with excellent chemo-, regio-, and stereoselectivity.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/cctc.201701016

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.