ChemCatChem
ChemCatChem
4 years ago

Direct Hydrogenation of a Broad Range of Amides under Base-free Conditions using an Efficient and Selective Ruthenium(II) Pincer Catalyst

Direct Hydrogenation of a Broad Range of Amides under Base-free Conditions using an Efficient and Selective Ruthenium(II) Pincer Catalyst
Qing-bin Liu, Yong Li, Gregory A. Solan, Wen-Hua Sun, Yanping Ma, Zheng Wang
The ruthenium(II) complex, [fac-PNHN]RuH(η1-BH4)(CO) (B; PNHN=8-(2-diphenylphosphinoethyl)aminotrihydroquinoline), is a highly versatile and effective catalyst (loadings of 0.1–1 mol %) for the hydrogenation of a multitude of amides, which include primary, secondary, and tertiary amides, to give their corresponding alcohols and amines in high yields under base-free conditions. All products were confirmed by using GC and GC–MS. Amide hydrogenation: A catalyst loading of between 0.1–1 mol % of the RuII complex B catalyzes the hydrogenation of a broad range of amides under base-free conditions efficiently and selectively to afford the corresponding alcohols and amines in high yields.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/cctc.201700952

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