ChemCatChem
ChemCatChem
4 years ago

Selective One-Pot Two-Step C−C Bond Formation using Metal–Organic Frameworks with Mild Basicity as Heterogeneous Catalysts

Selective One-Pot Two-Step C−C Bond Formation using Metal–Organic Frameworks with Mild Basicity as Heterogeneous Catalysts
Jorge A. R. Navarro, Dirk E. De Vos, Francisco G. Cirujano, Marleny Rodríguez-Albelo, Elisa Barea, Elena López-Maya
Copper-ion-exchanged nickel pyrazolate frameworks behave as selective heterogeneous catalysts for the one-pot, two-step (Henry reaction/Michael type addition) synthesis of neuroactive pharmaceutical intermediates starting from nitromethane and benzaldehyde. Tuning the basicity of multifunctional metal–organic framework catalysts through ion exchange with copper(II) cations allows the tandem C−C bond-forming process to be selectively directed towards the desired pharmaceutical intermediate. Two steps forward… Copper-exchanged metal–organic frameworks (MOFs) show tunable basicity, activity, and selectivity in C−C bond-forming reactions. Herein, these MOFs are used as selective heterogeneous catalysts for the one-pot, two-step (Henry reaction/Michael-type addition) synthesis of neuroactive pharmaceutical intermediates starting from nitromethane and benzaldehyde.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/cctc.201700784

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