3 years ago

Programmed Site-Selective Palladium-Catalyzed Arylation of Thieno[3,2-b]thiophene

Programmed Site-Selective Palladium-Catalyzed Arylation of Thieno[3,2-b]thiophene
Tung T. Dang, Hung-Huy Nguyen, T. M. Ha Vuong, Didier Villemin, Hien Nguyen, Tin Thanh Le
Mono-, di-, tri-, and tetraarylated thieno[3,2-b]thiophenes were synthesized by direct site-selective Pd-catalyzed C−H activation reactions with various aryl bromides in the presence of a phosphine-free Pd(OAc)2/KOAc catalyst system in N,N-dimethylacetamide (DMAc). The arylation of 2-arylthieno[3,2-b]thiophene took place at the C3 position if the 2-aryl substituents possessed electron-withdrawing groups and at the C5 position if they were bulky and possessed electron-donating groups. I C3 you C5: Mono-, di-, tri-, and tetraarylated thieno[3,2-b]thiophenes are synthesized by direct site-selective Pd-catalyzed C−H activation reactions with various aryl bromides in the presence of a phosphine-free Pd(OAc)2/KOAc catalyst system in N,N-dimethylacetamide (DMAc). The arylation takes place at the C-3 or C-5 position in the thieno[3,2-b]thiophene skeleton depending on the nature and size of the 2-aryl substituent.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/asia.201700562

You might also like
Never Miss Important Research

Researcher is an app designed by academics, for academics. Create a personalised feed in two minutes.
Choose from over 15,000 academics journals covering ten research areas then let Researcher deliver you papers tailored to your interests each day.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.