3 years ago

One-pot synthesis of ortho-acylphenols by palladium-catalyzed phenol C–H addition to nitriles

One-pot synthesis of ortho-acylphenols by palladium-catalyzed phenol C–H addition to nitriles
The regioselective one-pot synthesis of ortho-acylphenols via the palladium-catalyzed addition of phenols to nitriles and subsequent hydrolysis is reported. The acylation reaction proceeded smoothly using the Pd(OAc)2/DMSO system and TFA as the additive. This method also provides a direct strategy for the synthesis of a salicylketoxime scaffold.

Publisher URL: www.sciencedirect.com/science

DOI: S004040391731198X

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