3 years ago

Hydrogenolysis of geminal diazides

Hydrogenolysis of geminal diazides
The complete hydrogenolysis of compounds containing the geminal diazido functionality is described. Using hydrogen over palladium on charcoal, the diazides are reduced, and primary amines are obtained. For example, aminomalonates and glycines are generated in a straightforward manner. A protocol that provides direct access to acetylated amines derived from 2-amino-1,3-diketones in good to excellent yields, via hydrogenation in the presence of acetic anhydride, is also presented.

Publisher URL: www.sciencedirect.com/science

DOI: S0040403917312029

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