3 years ago

Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula
Sayed A. El-Toumy, Karla Frydenvang, Ahmed R. Hassan, John Nielsen, Søren Brøgger Christensen, Jesper Olsen, Truong Thanh Tung, Salah M. El-Kousy
A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the 14C content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis. The new natural product N-(4-hydroxyphenylethyl)-α-chloroferuloylamide was isolated as a mixture of the E and Z isomers along with a number of other well-established secondary metabolites.

Publisher URL: http://dx.doi.org/10.1021/acs.jnatprod.7b00106

DOI: 10.1021/acs.jnatprod.7b00106

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