3 years ago

One-pot synthesis of 3-hydroxy-2-oxindole-pyridine hybrids via Hantzsch ester formation, oxidative aromatization and sp3 CH functionalization using FeWO4 nanoparticles as recyclable heterogeneous catalyst

One-pot synthesis of 3-hydroxy-2-oxindole-pyridine hybrids via Hantzsch ester formation, oxidative aromatization and sp3 CH functionalization using FeWO4 nanoparticles as recyclable heterogeneous catalyst
Synthesis of poly-substituted 3-hydroxy-2-oxindole-pyridine hybrids is reported via sp3 CH bond functionalization as key steps using FeWO4 nanoparticles as reusable heterogeneous catalyst. Formation of Hantzsch ester (DHP) followed by aromatization, and sp3 CH bond functionalization was achieved using FeWO4 nanoparticles (20mol%) at 80°C. Temperature dependent reactivity was observed for mono aldol (at 80°C) and bis aldol (at 120°C) products. The catalyst was regenerated and reused up to 6cycles without losing catalytic activity. The FeWO4 nanoparticles were also used for oxidative aromatization of different DHP derivatives and for the sp3 CH functionalization of 2-methyl pyridine.

Publisher URL: www.sciencedirect.com/science

DOI: S1566736717304089

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.