3 years ago

Polymersomes as protocellular constructs

Polymersomes as protocellular constructs
Alexander F. Mason, Pall Thordarson
Despite the rapidly growing amount of knowledge on the structure and function of cells, they remain a distant bottom-up synthetic target due to their overwhelming complexity. A path to this goal is the development of protocellular systems that approximate one or more aspects of a natural cell. Polymer vesicles, or polymersomes, are an attractive scaffold for protocellular constructs, due to our ability to engineer the polymer membrane and generate a wide range of properties. This article summarizes the current state of polymersome science with respect to the properties and functions that lend these polymer-based systems to applications in synthetic cell research. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 3817–3825 Polymer vesicles, or polymersomes, are finding increased use in synthetic cell applications due to their robust and highly tuneable membranes. This review highlights examples of polymersome-based systems that exhibit structural and functional similarities to natural cells, such as structural and chemical asymmetry, stimuli-responsiveness, motility, and energy transduction.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/pola.28780

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