3 years ago

Tunable degradation of polyethylene glycol-like polymers based on imine and oxime bonds

Tunable degradation of polyethylene glycol-like polymers based on imine and oxime bonds
Zeyun Xiao, Joe Collins, Luke A. Connal
Hydrolytically degradable PEG-like polymers were prepared using oxime and/or imine chemistry. Polymers based on oxime linkages show higher stability than imine-based polymers. By blending the oxime and imine bonds, polymers with tuneable, two-stage degradation profiles could be prepared. Finally, end functional bioconjugates are prepared using unreacted hydroxylamine end groups.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/pola.28856

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