3 years ago

Immunomodulatory Nanomedicine

Immunomodulatory Nanomedicine
Matthias Bartneck
Immunity has a major impact on inflammatory diseases and cancer, and biologics targeting immune cells and their factors reach a quarter trillion of market volume by this year. Adaptive leukocytes have recently been engaged in cancer immunotherapy, whereas modulation of the innate immune cells, specifically macrophages, is expected as next breakthrough. With patents of major biologics expiring, nanomedicine has the potential to substitute therapeutic proteins by using miniaturized macromolecules. This review includes an overview on the involvement of major immune cell types into disease and a summary on selected current therapies based on biologics and small molecules. Novel developments in nanomedicine-based immunotherapies, including associated chances and risks, are presented. Immunomodulatory nanomedicine is on the run. The author summarizes state-of-the-art and novel concepts for immunomodulation by biologics, small molecules, and nanomedicine. Therapies on adaptive immune cells using biologics have successfully entered the clinics and demonstrated success in cancer therapy. In contrast, few novel therapeutics address the myeloid cells, such as macrophages.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/mabi.201700021

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