3 years ago

Nanoengineered Thermoresponsive Magnetic Nanoparticles for Drug Controlled Release

Nanoengineered Thermoresponsive Magnetic Nanoparticles for Drug Controlled Release
Amir Razmjou, Milad Jafari, Saeedeh Imanifard, Atefeh Zarepour, Arezoo Khosravi, Ali Zarrabi
Magnetic core–shell nanoparticles are one of the most interesting nanocarriers. Smart polymers can be attached to nanoparticles as a suitable shell. Cancer tissues, with higher temperature than normal one, are one of the best targets for these systems in which the polymeric shell shrinks and thus drugs are released. The aim of this research is to synthesize such a smart nanocarrier with a thermoresponsive shell. Magnetic nanoparticles are coated with poly(N-isopropylacrylamide). Afterward, the as prepared nanoparticles are analyzed through different characterization methods (scanning electron microscope, Fourier-transform infrared spectroscopy, carbon–hydrogen–nitrogen–sulfur elemental analysis, energy-dispersive X-ray spectroscopy) and their response to the temperature is investigated in different temperatures (37 and 40 °C). Results demonstrate that a biocompatible nanocarrier with the average size of about 35 nm and 83% entrapment efficiency for curcumin is successfully synthesized. The drug release process shows a controlled behavior over temperature. It has an increasing trend by increasing the temperature from 4 to 37 °C and then to 40 °C. Moreover, the cytotoxicity of drug loaded nanocarrier is obviously increased at 40 °C compared to 37 °C. It can be concluded that this new smart nanotheranostics agent can be successfully applied for cancer treatment. A new smart drug delivery system is synthesized based on coating superparamagnetic iron oxide nanoparticles (SPIONs) with a temperature sensitive polymer, poly(N-isopropylacrylamide), to improve the therapeutic efficacy of curcumin. This nanocarrier works by the on–off switching method and releases the drugs only when the environmental temperature is above its lower critical solution temperature, the same condition as of cancerous tissues.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/macp.201700350

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.