3 years ago

Multistructured Nanogel-Based Networks Formed from Interfacial Redox Polymerizations for Modulating Small Molecule Release

Multistructured Nanogel-Based Networks Formed from Interfacial Redox Polymerizations for Modulating Small Molecule Release
Jeffrey W. Stansbury, Travis Van De Veer, Tyler D'Ovidio, Devatha P. Nair, Eric A. Dailing
Uniform, 3D nanogel-based coatings are generated on polymeric substrates using an interfacial redox polymerization. Diffusion of a reducing agent from a core material into a solution of acrylate-functionalized nanogels and an oxidizer generates free radicals that initiate nanogel crosslinking selectively at the gel surface. Coating thickness is controlled between 20 and 150 µm by varying reaction time and initiator concentration. Controlling the structure of the final nanogel-based coating is demonstrated to predictably change the diffusion coefficient of a small molecule drug loaded into the core material. Multidrug release from the coating and the core is demonstrated with model dyes. This study showcases the ability to design multifunctional networks for controlled release using a simple, mild coating procedure. Crosslinked polymer gels can be conformally coated with polymerizable nanogels through an interfacially mediated redox reaction. Uniform, micrometer-scale coatings form rapidly at ambient, aqueous conditions. The structure of the nanogel coating controls the diffusion coefficient of a small molecule from the core polymer. Furthermore, the core polymer and nanogel coating may be separately loaded with different small molecules for multidrug release.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/macp.201700256

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