3 years ago

Cobalt-Catalyzed Oxidative Cyclization of Benzamides with Maleimides: Synthesis of Isoindolone Spirosuccinimides

Cobalt-Catalyzed Oxidative Cyclization of Benzamides with Maleimides: Synthesis of Isoindolone Spirosuccinimides
Masilamani Jeganmohan, Ramasamy Manoharan
The oxidative cyclization of substituted benzamides with maleimides assisted by 8-aminoquinoline in the presence of a catalytic amount of Co(OAc)2·4H2O provides isoindolone spirosuccinimides in good to excellent yields. The cyclization reaction was compatible with various substituted benzamides and maleimides. A possible reaction mechanism involving the C–H bond activation as a key step was proposed. The competition experiment and deuterium labeling studies were performed to investigate the mechanism of the reaction.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02873

DOI: 10.1021/acs.orglett.7b02873

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