Sensors and Actuators, B: Chemical
Sensors and Actuators, B: Chemical
5 years ago

A new fluorescent chemodosimeter for ultra-sensitive determination of toxic thiophenols in environmental water samples and cancer cells

A new fluorescent chemodosimeter for ultra-sensitive determination of toxic thiophenols in environmental water samples and cancer cells
A novel fluorescent chemodosimeter for thiophenols has been readily developed from a red emitting Indole-BODIPY. The chemodosimeter displays a significant fluorescence turn-on response towards thiophenols based on nucleophilic substitution reaction. A linear relationship was obtained between the fluorescence intensity and the concentrations of thiophenols ranging from 0 to 1.8μM. The chemodosimeter can determine thiophenols (4-fluorothiophenol, 4-methoxybenzenethiol, p-toluenethiol) with high selectivity, fast response (within 8min) and extremely low limit of detection (9.8nM). The chemodosimeter was successfully used to determine the level of thiophenol (PhSH) in industrial wastewater and Bohai Sea water with good recoveries. Furthermore, the chemodosimeter was employed to image thiophenols in cancer cells with good performance and low cytotoxicity. Therefore, this chemodosimeter has great potential application in environment.

Publisher URL: www.sciencedirect.com/science

DOI: S0925400517312455

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