3 years ago

Interplay between the folding mechanism and binding modes in folding coupled to binding processes

Interplay between the folding mechanism and binding modes in folding coupled to binding processes
Rajendra Sharma, Victor Munoz, David De Sancho
Proteins that fold upon binding to their partners exhibit complex binding behavior such as induced-fit. Using molecular simulations we find that the ability to bind via induced-fit requires the disordered protein to fold downhill. Thus induced-fit appears as a manifestation of a conformational rheostat.

Publisher URL: http://feeds.rsc.org/~r/rss/CP/~3/K15IQCaK5h4/C7CP04748G

DOI: 2017/CP/C7CP04748G

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