ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces
4 years ago

Facile Coordination-Precipitation Route to Insoluble Metal Roussin’s Black Salts for NIR-Responsive Release of NO for Anti-Metastasis

Facile Coordination-Precipitation Route to Insoluble Metal Roussin’s Black Salts for NIR-Responsive Release of NO for Anti-Metastasis
Kun Shi, Lijuan Chen, Liwei Xiong, Zhiyong Qian, Qianjun He, Zhaokui Jin, Tianfu Wang, Liwei Tan, Minyi Lei
A facile and general coordination-precipitation method is developed to synthesize insoluble metal Roussin’s black salts (Me-RBSs) as a new type of NIR-responsive NORMs. The weak-field ligand coordination of metal+–RBS– brings a NIR absorption effect of Me-RBSs, and further gives rise to the NIR adsorption-dependent NIR-responsive NO release profile. Intratumoral NIR-responsive release of NO effectively inhibits the growth and metastasis of the metastatic breast cancer. Aqueous insolubility of Me-RBSs ensures lower cytotoxicity and higher thermostability compared with traditional soluble RBSs. This work establishes a new class of NIR-sensitive NO donors, and may spark new inspiration for designing intelligent gas-releasing molecules.

Publisher URL: http://dx.doi.org/10.1021/acsami.7b11325

DOI: 10.1021/acsami.7b11325

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