5 years ago

Air-Stable Manganese(I)-Catalyzed C−H Activation for Decarboxylative C−H/C−O Cleavages in Water

Air-Stable Manganese(I)-Catalyzed C−H Activation for Decarboxylative C−H/C−O Cleavages in Water
Mélanie M. Lorion, Hui Wang, Lutz Ackermann
The decarboxylative C−H/C−O functionalization was accomplished by air- and water-tolerant manganese(I) catalysis. The versatile C−H allylation occurred by facile organometallic C−H metalation on indoles, arenes, amino acids and synthetically meaningful aryl ketimines with ample substrate scope and high levels of chemo-, site- and regio-selectivity. Manganese-catalyzed C−H activation: Robust organometallic manganese(I)-catalyzed C−H/C−O functionalizations enabled expedient decarboxylative diversifications of indoles, arenes, ketimines, and amino acids in air and H2O. Mechanistic experiments show the reversibility of the C−H metalation and the intermediacy of the metalacycle species.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201702193

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.