3 years ago

FUS Zigzags Its Way to Cross Beta

FUS Zigzags Its Way to Cross Beta
Rohit V. Pappu, Alex S. Holehouse

The low-complexity domain (LCD) of the FUS protein forms concentration-dependent assemblies, including liquid droplets and fibril-based hydrogels. The molecular structures of FUS within different assemblies and their functional relevance are subjects of intense debate. Murray et al. report an atomic-level structural model for FUS LCD fibrils that answers some questions and raises new ones.

Publisher URL: http://www.cell.com/cell/fulltext/S0092-8674(17)31191-1

DOI: 10.1016/j.cell.2017.10.007

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