3 years ago

Transforming Lipoxygenases: PE-Specific Enzymes in Disguise

Transforming Lipoxygenases: PE-Specific Enzymes in Disguise
Brent R. Stockwell, Ling F. Ye

In this issue of Cell, Wenzel et al. solve a long-standing mystery regarding how damage to cell membranes occurs during ferroptosis, an iron-dependent form of regulated cell death. They found that lipoxygenases are like Transformer toys, being converted from one enzyme type to another in the presence of the protein PEBP1.

Publisher URL: http://www.cell.com/cell/fulltext/S0092-8674(17)31190-X

DOI: 10.1016/j.cell.2017.10.006

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