3 years ago

Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation

Koji Atarashi, Jay K. Kolls, Hirokazu Yamagami, Mayuko Sato, Heba S. Said, Kong Chen, Keiko Yasuma, Seiko Narushima, Chengwei Luo, Ramnik J. Xavier, Yuya Kiguchi, Wataru Suda, Takeshi Tanoue, Hidetoshi Morita, Eran Elinav, Takaaki Kawaguchi, Eiichiro Watanabe, Masahira Hattori, Ryan C. Johnson, Kiminori Toyooka, Iori Motoo, Scott A. Rice, Christoph A. Thaiss, Kenya Honda, Julia A. Segre, Dirk Gevers

Intestinal colonization by bacteria of oral origin has been correlated with several negative health outcomes, including inflammatory bowel disease. However, a causal role of oral bacteria ectopically colonizing the intestine remains unclear. Using gnotobiotic techniques, we show that strains of Klebsiella spp. isolated from the salivary microbiota are strong inducers of T helper 1 (TH1) cells when they colonize in the gut. These Klebsiella strains are resistant to multiple antibiotics, tend to colonize when the intestinal microbiota is dysbiotic, and elicit a severe gut inflammation in the context of a genetically susceptible host. Our findings suggest that the oral cavity may serve as a reservoir for potential intestinal pathobionts that can exacerbate intestinal disease.

Publisher URL: http://science.sciencemag.org/cgi/content/short/358/6361/359

DOI: 10.1126/science.aan4526

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