The hippocampus is an important part of the brain which plays a role in the creation of new memories, regulates the relationship between short-term and long-term memory, spatial orientation and spatial memory. In the period 25th May – 14th June, Researcher Live will explore latest research into the neurology of the hippocampus in our three-part series 'Hippocampal Neurons: morphology, function, regeneration'. Sign up here to stay up to date with this series!
Join us at 9am BST / 8am GMT on the 14th June for the third episode in this three-part series, with Prof Thomas Fath, Macquarie Medical School.
- 25th May, 2pm BST - Prof Walace Gomes Leal - Professor of Experimental Neuropathology and Neuroimmunology. Federal University of Western Pará ‘Mental health and adult hippocampal neurogenesis: the neural symbiosis’
- 6th June, 2pm BST - Dr Francesco Tamagnini , Lecturer in Pharmacology, University of Reading ‘Inhibitory neuron hyperexcitability in progressive tauopathy’
- 14th June, 9am BST - Prof Professor Thomas Fath, Macquarie University ‘Using hippocampal cell culture models to study neuronal morphogenesis and function’
Primary neuron cultures have been used for several decades to decipher key mechanisms of neuronal development and mechanisms of disease. In this talk, we will discuss established techniques and recent advances in the culturing of mouse primary neurons and the use of cell culture devices that allow us to manipulate and visualise dynamic processes in neuronal function and dysfunction. A focus of the discussion will be how primary neuronal cultures have provided us with new insights into the actin cytoskeleton-dependent regulation of neurite growth in developing neurons.
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Prof Thomas Fath is Deputy Director of the Dementia Research Centre and Professor in the Department of Biomedical Sciences of the Faculty of Medicine and Health Sciences at Macquarie University. Previous to this, he was the Head of the Neurodegeneration and Repair Unit (NRU) and Head of the Neuronal Culture Core Facility (NCCF) at UNSW. He received his PhD in 2002 from the University of Heidelberg, where he worked on the functional role of Tau phosphorylation in Alzheimer's disease. He then moved to The Scripps Research Institute at La Jolla (2003-2005, USA), shifting his research focus to the study of the actin cytoskeleton in neuronal function and morphogenesis. After this, Dr Fath continued his work on the actin cytoskeleton in neurons at the Children's Hospital at Westmead (2005-2008). In 2009, he took on a Research & Teaching position in the School of Medical Sciences at UNSW Sydney, where he established an ARC and NHMRC-funded research program, investigating cytoskeleton-associated patho-mechanisms of Neurodegenerative diseases and mechanisms of neurite regeneration.
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