3 years ago

Cracking the Vaccine Code in Tuberculosis.

Maziar Divangahi, Marcel A Behr
Considerable effort has been devoted to developing a T cell mediated vaccine against tuberculosis (TB).  However, to date, the evidence that this approach can provide protection against Mycobacterium tuberculosis infection has been limited in pre-clinical models and disappointing in a clinical trial. Our fundamental lack of understanding of protective immunity against TB is still the major impediment to vaccine development. In this perspective article, we aim to distinguish the innate immune mechanisms of host-resistance from T cell mediated host-tolerance, and call for novel approaches to be investigated, in the quest for a new TB vaccine.

Publisher URL: http://doi.org/10.1164/rccm.201707-1489PP

DOI: 10.1164/rccm.201707-1489PP

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