3 years ago

In-vitro physiologically based extraction of solid materials: Do we have reliable analytical methods for bioaccessibility studies of emerging organic contaminants?

In-vitro physiologically based extraction of solid materials: Do we have reliable analytical methods for bioaccessibility studies of emerging organic contaminants?
In-vitro oral bioaccessibility tests do remain alluring as viable tools for fast assessment of potential human exposure to environmental contaminants to comply with the ethical constraints posed by the REACH guidelines. A variety of biologically-relevant extraction methods to measure solubility of organic compounds as a proxy for bioaccessibility in the human body using mock digestive fluids have been proposed over the past decade as integral part of holistic exposome studies. However, analytical methods in several instances are not properly validated and do not report proper quality control/quality assurance (QA/QC) issues. This review provides insights into the analytical validation of physiologically relevant gastrointestinal assays for organic contaminants (namely, organophosphate and brominated flame retardants, fluorinated organic species, and (myco)toxins) in risk assessment studies of potentially contaminated environmental solids and (sea)food commodities. Sample preparation and (micro)extraction methods for processing of the gastrointestinal extracts prior to liquid chromatography (LC)/LC-mass spectrometry (MS) and gas chromatography (GC)-MS assays are critically evaluated. We also propose a fully detailed analytical workflow embracing QA/QC tools to serve as a tutorial for proper validation of new physiologically-based extraction tests.

Publisher URL: www.sciencedirect.com/science

DOI: S0165993617300249

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