3 years ago

Activity of Meropenem-Vaborbactam Against Carbapenem-resistant Enterobacteriaceae in a Murine Model of Pyelonephritis.

Jessica Silva, Mark E Pulse, Mojgan Sabet, Phung Nguyen, Jerry W Simecka, William J Weiss, Kelly Peterson, David C Griffith, David Valtierra
The recently approved combination of meropenem-vaborbactam (Vabomere™) is highly active against Gram-negative pathogens, especially KPC-producing, carbapenem-resistant Enterobacteriaceae We evaluated the efficacy of meropenem-vaborbactam against three clinically relevant isolates in a murine polynephritis model. Data indicated that the combination of meropenem-vaborbactam significantly increased the bacterial killing compared to the untreated controls. These data suggest that this combination may have utility in the treatment of complicated urinary tract infections due to KPC-producing, carbapenem-resistant Enterobacteriaceae.

Publisher URL: http://doi.org/10.1128/AAC.01439-17

DOI: 10.1128/AAC.01439-17

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