3 years ago

Curcumin: A Naturally Occurring Modulator of Adipokines in Diabetes

Curcumin: A Naturally Occurring Modulator of Adipokines in Diabetes
Amirhossein Sahebkar, Amir Abbas Momtazi, Jafar Hajavi, Maciej Banach, Thomas P. Johnston, Muhammed Majeed
Curcumin, the bioactive component of turmeric, has been used for the treatment of several diseases including diabetes and its complications. Curcumin has been shown to exert pleiotropic effects by modulating different signaling molecules, including transcription factors, chemokines, cytokines, and adipokines. Disturbed regulation of adipokines, which include adiponectin, leptin, resistin, and visfatin, are implicated in the development of insulin resistance and Type 2 diabetes. Here, we review the findings of in vitro, in vivo, and clinical studies on the modulating effects that curcumin treatment exerts on adipokines. Additionally, we examine the potential beneficial effects of the activity of curcumin in the prevention and treatment of diabetes and its comorbidities. J. Cell. Biochem. 118: 4170–4182, 2017. © 2017 Wiley Periodicals, Inc. Here, we review the findings of in vitro, in vivo, and clinical studies on the modulating effects of curcumin treatment on adipokines, and the potential beneficial effects of this activity of curcumin in the prevention and treatment of diabetes and its comorbidities.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/jcb.26121

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