5 years ago

Plasmonic Photothermal Gold Bipyramid Nanoreactors for Ultrafast Real-Time Bioassays

Plasmonic Photothermal Gold Bipyramid Nanoreactors for Ultrafast Real-Time Bioassays
Bozhi Tian, Jung-Hoon Lee, Zoya Cheglakov, Yossi Weizmann, Kyle J. Gibson, Jaeseok Yi, Timothy M. Cronin
Nucleic acid amplification techniques have been among the most powerful tools for biological and biomedical research, and the vast majority of the bioassays rely on thermocycling that uses time-consuming and expensive Peltier-block heating. Here, we introduce a plasmonic photothermal method for quantitative real-time PCR, using gold bipyramids and light to achieve ultrafast thermocycling. Moreover, we successfully extend our photothermal system to other biological assays, such as isothermal nucleic acid amplification and restriction enzyme digestion.

Publisher URL: http://dx.doi.org/10.1021/jacs.7b01779

DOI: 10.1021/jacs.7b01779

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