3 years ago

Optical emission of 223Radium: in vitro and in vivo preclinical applications

Francesco De Sanctis, Federico Boschi, Antonello E. Spinelli
223Radium (223Ra) is widely used in Nuclear medicine to treat patients with osseous metastatic prostate cancer. In clinical practice 223Ra cannot be imaged directly, however gamma photons produced by its short-lived daughter nuclides can be captured by conventional gamma cameras. In this work we show that 223Ra and its short-lived daughter nuclides can be detected with optical imaging techniques. The light emission of 223Ra was investigated in vitro using different setups in order to clarify the mechanism of light production. The results demonstrate that the luminescence of the 223Ra chloride solution, usually employed in clinical treatments, is compatible with Cerenkov luminescence having an emission spectrum that is almost indistinguishable from Cerenkov radiation one. This study proves that luminescence imaging can be successfully employed to detect 223Ra in vivo in mice by imaging whole body 223Ra biodistribution and more precisely its uptake in bones.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/jbio.201700209

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