3 years ago

Inside Front Cover: Inside Front Cover: Quantitative proteomic analysis of host epithelial cells infected by Salmonella enterica serovar Typhimurium

Inside Front Cover: Inside Front Cover: Quantitative proteomic analysis of host epithelial cells infected by Salmonella enterica serovar Typhimurium
Mo Hu, Kaiwen Yu, Xiaoyun Liu, Yanhua Liu, Mei Wu, Linlu Qi, Jiaqi Fu
DOI: 10.1002/pmic.201700092Salmonella infection is a great model system to study host-pathogen interactions. Quantitative proteomics analysis of Salmonella-infected epithelial cells revealed that host integrin proteins and glycolytic pathways were markedly induced while nuclear RNA metabolism proteins were down-regulated. Importantly, we found higher levels of nuclear PARP1 in infected cells, an event likely specific to Salmonella infection. This work demonstrates that unbiased high-throughput proteomics can be used as a powerful approach to provide new perspectives on host-pathogen interactions. For more details, see the research article by Linlu Qi et al., article number 1700092.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/pmic.201770112

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