3 years ago

Genetic Constructor: An Online DNA Design Platform

Genetic Constructor: An Online DNA Design Platform
Deepak Chandran, Eli Groban, Joe Lachoff, Maxwell Bates, Rupal Khilari, Anaïs Moisy, Hille Tekotte, Cornelia Johanna Franziska Scheitz, Yisha Luo, Valentin Zulkower, Duncan Meech, Florencio Mazzoldi
Genetic Constructor is a cloud Computer Aided Design (CAD) application developed to support synthetic biologists from design intent through DNA fabrication and experiment iteration. The platform allows users to design, manage, and navigate complex DNA constructs and libraries, using a new visual language that focuses on functional parts abstracted from sequence. Features like combinatorial libraries and automated primer design allow the user to separate design from construction by focusing on functional intent, and design constraints aid iterative refinement of designs. A plugin architecture enables contributions from scientists and coders to leverage existing powerful software and connect to DNA foundries. The software is easily accessible and platform agnostic, free for academics, and available in an open-source community edition. Genetic Constructor seeks to democratize DNA design, manufacture, and access to tools and services from the synthetic biology community.

Publisher URL: http://dx.doi.org/10.1021/acssynbio.7b00236

DOI: 10.1021/acssynbio.7b00236

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