3 years ago

Squaramide–Sulfonamide Organocatalyst for Asymmetric Direct Vinylogous Aldol Reactions

Squaramide–Sulfonamide Organocatalyst for Asymmetric Direct Vinylogous Aldol Reactions
Tsuyoshi Miura, Takaaki Sakai, Yuji Koseki, Kosuke Nakashima, Yoshifumi Yamashita, Ryoga Arai, Shin-ichi Hirashima, Akihiro Yoshida
Asymmetric direct vinylogous aldol reactions of furan-2(5H)-one with aldehydes in the presence of a catalytic amount of novel squaramide–sulfonamide organocatalyst resulted in the corresponding addition products with high to excellent enantioselectivities. This is the first successful report illustrating an example of highly stereoselective reactions using a squaramide–sulfonamide organocatalyst.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00287

DOI: 10.1021/acs.joc.7b00287

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