3 years ago

New generation nanomedicines constructed from self-assembling small molecule prodrugs alleviate cancer drug toxicity.

Hui Li, Liqian Zhou, Tingting Guo, Xiao Xu, Zhen Li, Shusen Zheng, Hangxiang Wang, Zhongjie Lu, Lin Zhou, Haiyang Xie, Penghong Song, Lijiang Wang, Donghai Jiang, Jiaping Wu, Jianqin Wan
The therapeutic index for chemotherapeutic drugs is determined in part by systemic toxicity, so strategies for dose intensification to improve efficacy must also address tolerability. In addressing this issue, we have investigated a novel combinatorial strategy of reconstructing a drug molecule and using sequential drug-induced nanoassembly to fabricate supramolecular nanomedicines (SNM). Using cabazitaxel (CTX) as a target agent, we established that individual synthetic prodrugs tethered with polyunsaturated fatty acids were capable of recapitulating self-assembly behavior independent of exogenous excipients. The resulting SNM could be further refined by PEGylation with amphiphilic copolymers suitable for preclinical studies. Among these CTX derivatives, docosahexaenoic acid-derived compound 1 retained high anti-proliferative activity. SNM assembled with compound 1 displayed an unexpected enhancement of tolerability in animals along with effective therapeutic efficacy in a mouse xenograft model of human cancer, compared to free drug administered in its clinical formulation. Overall, our studies showed how attaching flexible lipid chains to a hydrophobic and highly toxic anticancer drug can convert it to a systemic self-deliverable nanotherapy, preserving its pharmacological efficacy while improving its safety profile.

Publisher URL: http://doi.org/10.1158/0008-5472.CAN-17-0984

DOI: 10.1158/0008-5472.CAN-17-0984

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